The discovery enables researchers to create finely-detailed, biocompatible structures, such as this scaffold for tissue engineering. Image Citation: Regen. Med. 8(6), 725–738 (2013).

Permian Plastics is active in the medical device plastic injection molding industry.  This news article from Medical Design Technology shares research on a non-toxic polymer that can open up the field of 3D printing for implanting structures. That is an ideal addition to medical device technologies.

Medical Implants 3D Printing Innovation in Medical Device Production

by North Carolina State University

October 23, 2013

Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and Laser Zentrum Hannover have discovered that a naturally-occurring compound can be incorporated into three-dimensional (3-D) printing processes to create medical implants out of non-toxic polymers. The compound is riboflavin, which is better known as vitamin B2.

“This opens the door to a much wider range of biocompatible implant materials, which can be used to develop customized implant designs using 3-D printing technology,” says Dr. Roger Narayan, senior author of a paper describing the work and a professor in the joint biomedical engineering department at NC State and UNC-Chapel Hill.

The researchers in this study focused on a 3-D printing technique called two-photon polymerization, because this technique can be used to create small objects with detailed features – such as scaffolds for tissue engineering, microneedles or other implantable drug-delivery devices.

Two-photon polymerization is a 3-D printing technique for making small-scale solid structures from many types of photoreactive liquid precursors. The liquid precursors contain chemicals that react to light, turning the liquid into a solid polymer. By exposing the liquid precursor to targeted amounts of light, the technique allows users to “print” 3-D objects.

Two-photon polymerization has its drawbacks, however. Most chemicals mixed into the precursors to make them photoreactive are also toxic, which could be problematic if the structures are used in a medical implant or are in direct contact with the body.

But now researchers have determined that riboflavin can be mixed with a precursor material to make it photoreactive. And riboflavin is both nontoxic and biocompatible – it’s a vitamin found in everything from asparagus to cottage cheese.

The paper, “Two-photon polymerization of polyethylene glycol diacrylate scaffolds with riboflavin and triethanolamine used as a water-soluble photoiniator,” is published online in Regenerative Medicine. Lead author of the paper is Alexander Nguyen, a Ph.D. student in NC State and UNC-Chapel Hill’s joint biomedical engineering program. Co-authors include Shaun Gittard, Anastasia Koroleva, Sabrina Schlie, Arune Gaidukeviciute and Boris Chichkov of Laser Zentrum Hannover. The research was supported by National Science Foundation grant 0936110.

Shared by Permian Plastics, a medical device plastic injection molding company.